Population pharmacokinetics/pharmacodynamics of anesthetics
نویسندگان
چکیده
منابع مشابه
Local Anesthetics Properties of Local Anesthetics
The first clinical uses of a local anesthetic agent occurred in 1884, when cocaine was employed as a topical agent for eye surgery and to produce a nerve block. These events inaugurated a new era, that of regional anesthesia. New applications were developed, including spinal, epidural, and caudal anesthesia. The search for a better local anesthetic led to chemical synthesis of a number of other...
متن کاملToxicity of local anesthetics
Systemic neurotoxicity due to excessive cerebral local anesthetic blood levels is one of the most severe and most frequent adverse outcome of local anesthetic use. Toxic levels are most often produced by unintentional intravenous or intraarterial injection(1,2). Toxicity can also result from the rapid absorption of drug following perineural injection. Peak blood levels are usually obtained acco...
متن کامل[Neuroprotective effects of anesthetics].
During cerebral ischaemia, energetic failure of injured cells together with excessive release of glutamate the most common excitatory amino acid in the brain, lead to excitotoxicity and immediate or delayed neuronal death. There is strong experimental evidence to support the neuroprotective role played by anaesthetic agents. Hence, barbiturates, volatile anesthetics or ketamine exhibit signific...
متن کاملMechanisM of LocaL anesthetics
Local anesthetic systemic toxicity (LAST) is a rare yet devastating complication from the administration of local anesthesia. The ability to recognize and treat LAST is critical for clinicians who administer these drugs. The authors reviewed the literature on the mechanism, treatment, and prevention of LAST, with the goal of proposing a practical method for its management.
متن کاملChoice of anesthetics.
The choice of anesthetics for vascular surgical patients is not only determined by the kind and extent of the surgical procedure but also by patient comorbidities. Frequently, patients have a history of hypertension, peripheral vascular and coronary artery disease,cerebrovascular disease, and renal impairment. The goal of the chosen anesthetic technique is to protect organ function, mainly of t...
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ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2005
ISSN: 1550-7416
DOI: 10.1208/aapsj070239